Across TCGA pan-cancer cohorts, TRAJ42 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRAJ42’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAJ42 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ42 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, STAD, and HNSC are the cancer types where TRAJ42 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAJ42 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.202	.001	6	view →
STAD	Female	III,IV	+2.675	.007	2	view →
HNSC	Male	All	+0.152	.048	2	view →
LUSC	Male	III,IV	−0.837	.034	1	view →
LUAD	All	All	+0.378	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TRAJ42 RNA expression & survival · all TRAJ42 data types