TRAF3IP3

Across TCGA patient cohorts, TRAF3IP3 mutation is significantly associated with the RNA expression of many other genes, with 2,031 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF3IP3-associated genes across cancer lineages are TUBA1C, CKS1B, and CEP89. Each is linked with TRAF3IP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAF3IP3-to-partner and partner-to-TRAF3IP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBA1C grouped by TRAF3IP3-low versus TRAF3IP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF3IP3→partner) and Y-score (partner→TRAF3IP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBA1C →	+0.608	+2.502	.008	.002	3	3
SKCM	CKS1B →	+0.422	+2.497	.006	.009	3	3
SKCM	CEP89 →	+0.313	+2.321	.004	.005	3	3
UCEC	KDM1A →	+0.547	+3.480	<.001	.002	3	3
UCEC	WDR62 →	+0.677	+3.606	<.001	.001	3	3
UCEC	CDC45 →	+0.666	+2.716	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,031 associations by consensus.

TUBA1C by TRAF3IP3 expression — UCEC

Explore this box plot interactively →