TRAF3IP3

Across TCGA pan-cancer cohorts, TRAF3IP3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TRAF3IP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAF3IP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAF3IP3 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where TRAF3IP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAF3IP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.271	<.001	11	view →
HNSC	Male	All	+0.544	<.001	9	view →
LUSC	All	All	−0.499	.001	7	view →
COAD	Female	II,III,IV	−0.618	<.001	6	view →
STAD	Female	All	+1.200	.023	4	view →
BRCA	All	All	+0.432	<.001	4	view →
THCA	Male	IV	+0.750	.004	2	view →
UCEC	All	All	−0.270	.019	2	view →
CHOL	All	All	+0.740	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TRAF3IP3–KIRC

Open the KIRC breakdown →