TRAF3IP3

Across TCGA patient cohorts, TRAF3IP3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF3IP3-associated genes across cancer lineages are Tuberin, PDCD4, and 4E-BP1. Each is linked with TRAF3IP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAF3IP3-to-partner and partner-to-TRAF3IP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by TRAF3IP3-low versus TRAF3IP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF3IP3→partner) and Y-score (partner→TRAF3IP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.399	+3.469	<.001	.002	3	3
UCEC	PDCD4 →	-0.617	-2.807	.002	.003	3	2
UCEC	4E-BP1 →	+0.262	+3.199	.027	.009	3	2
SKCM	YAP_pS127 →	-0.365	-3.459	.013	.005	3	1
UCEC	EGFR_pY1068 →	-0.245	-2.115	.025	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.317	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Tuberin by TRAF3IP3 expression — UCEC

Explore this box plot interactively →