TRAF3IP3

Across TCGA cell cohorts, TRAF3IP3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TRAF3IP3-associated genes across cancer lineages are PF4, DYNAP, and OR8B3. Each is linked with TRAF3IP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF3IP3-to-partner and partner-to-TRAF3IP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PF4 grouped by TRAF3IP3-low versus TRAF3IP3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF3IP3→partner) and Y-score (partner→TRAF3IP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PF4 →	+0.031	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	DYNAP →	+0.161	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR8B3 →	+0.055	+5.209	<.001	.005	3	1
BREAST	SLC22A6 →	+0.006	+5.781	<.001	.001	3	1
BREAST	MLN →	+0.071	+5.169	<.001	.005	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PF4 by TRAF3IP3 expression — BLOOD_Lymphoma

Explore this box plot interactively →