TRAF2

Across TCGA pan-cancer cohorts, TRAF2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TRAF2 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRAF2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TRAF2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LSCC, and OV are the cancer types where TRAF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.946	0.467	.002	32	view →
LSCC	DFS	Tertile	II,III,IV	0.798	1.000	.012	10	view →
OV	DFS	Median	All	0.843	1.000	.026	4	view →
PDAC	OS	Quartile	III,IV	0.442	1.000	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TRAF2–UCEC (DFS)

Open the UCEC breakdown →