TRAF2

Across TCGA pan-cancer cohorts, TRAF2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TRAF2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAF2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAF2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where TRAF2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAF2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.180	<.001	12	view →
HNSC	Male	All	+0.950	<.001	12	view →
BLCA	Male	III,IV	+1.115	<.001	11	view →
COAD	Male	III,IV	+0.898	<.001	11	view →
KIRP	All	IV	+1.939	<.001	9	view →
STAD	Male	III,IV	+1.899	<.001	9	view →
LIHC	Female	II,III,IV	+1.850	<.001	9	view →
LUAD	Male	III,IV	+0.969	<.001	9	view →
THCA	Male	IV	−0.689	<.001	9	view →
BRCA	All	III,IV	+0.985	<.001	6	view →
LUSC	All	II,III,IV	+0.824	<.001	6	view →
UCEC	All	All	+0.449	.003	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TRAF2–KIRC

Open the KIRC breakdown →