TRAF2

Across TCGA patient cohorts, TRAF2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF2-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with TRAF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF2-to-partner and partner-to-TRAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TRAF2-low versus TRAF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF2→partner) and Y-score (partner→TRAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.439	+2.584	.008	.011	3	1
UCEC	EGFR_pY1068 →	-0.307	-3.321	.008	.010	3	1
UCEC	ERK2 →	+0.306	+3.700	<.001	.001	3	1
UCEC	FoxM1 →	+0.266	+3.179	.027	.010	3	1
UCEC	NF2 →	+0.222	+2.999	.027	.035	3	1
UCEC	PEA-15_pS116 →	+0.382	+2.321	.019	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eEF2 by TRAF2 expression — UCEC

Explore this box plot interactively →