TRAF2

Across TCGA cell cohorts, TRAF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,339 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TRAF2-associated GO terms across cancer lineages are Regulation of DNA-templated DNA replication, CTP salvage, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with TRAF2 in more than 14 cancer types. Because this analysis shows association rather than direction, both TRAF2-to-partner and partner-to-TRAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated DNA replication grouped by TRAF2-low versus TRAF2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF2→partner) and Y-score (partner→TRAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of DNA-templated DNA replication →	+0.097	+0.966	<.001	<.001	3	15
SOFT_TISSUE	CTP salvage →	+0.127	+0.932	<.001	<.001	3	14
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.207	+0.949	<.001	.001	3	12
SOFT_TISSUE	Positive regulation of DNA-templated DNA replication →	+0.117	+0.984	<.001	<.001	3	12
URINARY_TRACT	Protein-containing complex disassembly →	+0.068	+1.126	<.001	<.001	3	12
BONE	Protein localization to cytoskeleton →	+0.089	+0.887	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,339 associations by consensus.

Regulation of DNA-templated DNA replication by TRAF2 expression — BONE

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