TRAF2

Across TCGA cell cohorts, TRAF2 mutation is significantly associated with the drug of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAF2-associated genes across cancer lineages are CCT007093, Fulvestrant, and Sabutoclax. Each is linked with TRAF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF2-to-partner and partner-to-TRAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT007093 grouped by TRAF2-low versus TRAF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF2→partner) and Y-score (partner→TRAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCT007093 →	+0.353	+2.649	.017	.046	3	1
LARGE_INTESTINE	Fulvestrant →	+0.366	+2.649	.026	.046	3	1
LARGE_INTESTINE	Sabutoclax →	+0.411	+2.991	.041	.018	3	1
LARGE_INTESTINE	WZ3105 →	+0.761	+2.874	.019	.021	3	1
LARGE_INTESTINE	PHA-793887 →	+0.688	+2.874	.048	.021	3	1
LARGE_INTESTINE	UNC1215 →	+0.233	+2.716	.022	.042	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

CCT007093 by TRAF2 expression — LARGE_INTESTINE

Explore this box plot interactively →