TRAC

Across TCGA patient cohorts, TRAC mutation is significantly associated with the RNA expression of many other genes, with 2,599 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAC-associated genes across cancer lineages are RPL12P5, MIR5586, and CDKN3. Each is linked with TRAC in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAC-to-partner and partner-to-TRAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P5 grouped by TRAC-low versus TRAC-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAC→partner) and Y-score (partner→TRAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RPL12P5 →	+0.241	+3.623	.002	.008	3	2
STAD	MIR5586 →	+0.292	+3.859	.004	.003	3	2
UCEC	CDKN3 →	+0.612	+2.914	.003	.001	3	2
UCEC	CYP27B1 →	+0.668	+2.970	<.001	<.001	3	2
UCEC	PFDN1 →	+0.271	+1.801	.007	.004	3	2
UCEC	CCDC62 →	+0.159	+2.234	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,599 associations by consensus.

RPL12P5 by TRAC expression — STAD

Explore this box plot interactively →