TRA2B

Across TCGA patient cohorts, TRA2B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRA2B-associated genes across cancer lineages are A-Raf_pS299, GAPDH, and JNK2. Each is linked with TRA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TRA2B-to-partner and partner-to-TRA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TRA2B-low versus TRA2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRA2B→partner) and Y-score (partner→TRA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.101	-3.321	.019	.009	3	1
UCEC	GAPDH →	+0.446	+1.925	.020	.005	3	1
UCEC	JNK2 →	+0.315	+2.424	<.001	.001	3	1
UCEC	Ku80 →	+0.260	+1.939	.002	.003	3	1
UCEC	MEK1 →	+0.295	+2.459	.025	.018	3	1
UCEC	NF2 →	+0.201	+2.999	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

A-Raf_pS299 by TRA2B expression — UCEC

Explore this box plot interactively →