TRA2B

Across TCGA pan-cancer cohorts, TRA2B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated TRA2B data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TRA2B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRA2B expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

ACC, KIRC, and LIHC are the cancer types where TRA2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.382	0.770	<.001	80	view →
KIRC	DFS	Tertile	All	0.774	0.506	<.001	69	view →
LIHC	OS	Tertile	All	0.682	0.833	.001	48	view →
LGG	DFS	Median	All	0.785	0.880	<.001	37	view →
LUAD	DFS	Tertile	II,III,IV	0.601	0.828	.008	35	view →
ESCA	OS	Tertile	III,IV	0.371	0.718	.003	35	view →
KICH	DFS	Median	II,III,IV	0.575	0.920	.006	32	view →
UVM	DFS	Quartile	III,IV	0.216	1.000	.006	26	view →
THYM	OS	Tertile	All	1.000	0.748	.006	21	view →
UCS	OS	Quartile	II,III,IV	0.655	0.221	.004	18	view →
GBM	DFS	Median	All	0.404	0.183	.001	17	view →
READ	OS	Quartile	All	0.939	0.283	.008	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

TRA2B–ACC (DFS)

Open the ACC breakdown →