Across TCGA pan-cancer cohorts, TPT1P14 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TPT1P14’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TPT1P14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TPT1P14 is over-expressed in tumor, although a few such as LIHC and COAD show the opposite, repressed pattern.
KIRC, HNSC, and LUAD are the cancer types where TPT1P14 tumor–normal differential expression is most reproducible.