TPT1

Across TCGA patient cohorts, TPT1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPT1-associated genes across cancer lineages are p70-S6K, AMPK_pT172, and EGFR_pY1173. Each is linked with TPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPT1-to-partner and partner-to-TPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by TPT1-low versus TPT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPT1→partner) and Y-score (partner→TPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.244	+2.833	.038	.035	3	1
UCEC	AMPK_pT172 →	+0.501	+2.820	.046	.036	3	1
UCEC	EGFR_pY1173 →	+0.097	+2.833	.048	.035	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p70-S6K by TPT1 expression — UCEC

Explore this box plot interactively →