TPT1

Across TCGA pan-cancer cohorts, TPT1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TPT1 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TPT1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TPT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and MESO show a favorable association.

UCEC, MESO, and OV are the cancer types where TPT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.887	0.768	.001	88	view →
MESO	OS	Tertile	II,III,IV	0.486	0.251	.002	80	view →
OV	OS	Tertile	II,III,IV	0.238	0.354	.001	58	view →
BRCA	DFS	Tertile	All	0.573	0.492	.002	46	view →
BLCA	OS	Tertile	IV	0.163	0.362	.003	44	view →
ACC	DFS	Median	All	0.159	0.620	<.001	43	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	40	view →
HNSC	DFS	Quartile	All	0.622	0.819	<.001	37	view →
KICH	DFS	Quartile	II,III,IV	0.408	0.851	.012	36	view →
THCA	OS	Median	II,III,IV	0.992	0.960	.005	36	view →
KIRC	DFS	Tertile	III,IV	0.709	0.559	.008	27	view →
LGG	DFS	Quartile	All	0.827	0.639	<.001	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TPT1–UCEC (DFS)

Open the UCEC breakdown →