TPT1

Across TCGA cell cohorts, TPT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,451 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TPT1-associated GO terms across cancer lineages are Spindle midzone assembly, Mitotic spindle midzone assembly, and Mitotic spindle elongation. Each is linked with TPT1 in more than 10 cancer types. Because this analysis shows association rather than direction, both TPT1-to-partner and partner-to-TPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle midzone assembly grouped by TPT1-low versus TPT1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPT1→partner) and Y-score (partner→TPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Spindle midzone assembly →	-0.188	-0.794	<.001	<.001	3	11
OESOPHAGUS	Mitotic spindle midzone assembly →	-0.233	-0.676	.001	.006	3	11
OESOPHAGUS	Mitotic spindle elongation →	-0.233	-0.676	.001	.006	3	11
OESOPHAGUS	Mitotic chromosome condensation →	-0.151	-0.736	<.001	<.001	3	9
BONE	Multi-pass transmembrane protein insertion into ER membrane →	-0.111	-0.743	.001	<.001	3	9
URINARY_TRACT	Negative regulation of cilium assembly →	-0.073	-0.771	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,451 associations by consensus.

Spindle midzone assembly by TPT1 expression — LARGE_INTESTINE

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