TPST2

Across TCGA patient cohorts, TPST2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPST2-associated genes across cancer lineages are ERK2, Caspase-8, and 4E-BP1. Each is linked with TPST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPST2-to-partner and partner-to-TPST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TPST2-low versus TPST2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPST2→partner) and Y-score (partner→TPST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.275	+3.321	.006	.010	3	1
UCEC	Caspase-8 →	-0.331	-3.295	.012	.009	3	1
UCEC	4E-BP1 →	+0.353	+2.837	.012	.035	3	1
UCEC	Cyclin-E2 →	+0.207	+2.817	.019	.036	3	1
UCEC	Ku80 →	+0.401	+3.009	.001	.019	2	1
UCEC	Bak →	+0.383	+3.000	.003	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ERK2 by TPST2 expression — UCEC

Explore this box plot interactively →