TPST2

Across TCGA cell cohorts, TPST2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TPST2-associated genes across cancer lineages are IQCF1, SRY, and GUCA2A. Each is linked with TPST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPST2-to-partner and partner-to-TPST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF1 grouped by TPST2-low versus TPST2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPST2→partner) and Y-score (partner→TPST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF1 →	+0.085	+3.769	<.001	.008	3	1
BLOOD_Leukemia	SRY →	+0.022	+3.874	.001	.005	3	1
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IQCF1 by TPST2 expression — BLOOD_Leukemia

Explore this box plot interactively →