TPST1

Across TCGA cell cohorts, TPST1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TPST1-associated genes across cancer lineages are DPPA2, SPATA31A6, and FAM47C. Each is linked with TPST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPST1-to-partner and partner-to-TPST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPPA2 grouped by TPST1-low versus TPST1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPST1→partner) and Y-score (partner→TPST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DPPA2 →	+0.218	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	SPATA31A6 →	+0.022	+4.643	<.001	.005	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	CLCN1 →	+0.028	+4.058	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DPPA2 by TPST1 expression — BLOOD_Lymphoma

Explore this box plot interactively →