TPRN

Across TCGA patient cohorts, TPRN protein abundance is significantly associated with the RNA expression of many other genes, with 13,738 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TPRN-associated genes across cancer lineages are TMEM237, BLMH, and FGD1. Each is linked with TPRN in more than 4 cancer types. Because this analysis shows association rather than direction, both TPRN-to-partner and partner-to-TPRN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPRN versus TMEM237 in LSCC, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRN→partner) and Y-score (partner→TPRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMEM237 →	-0.575	-0.174	.002	.005	3	5
OV	BLMH →	-0.662	-0.456	<.001	<.001	3	4
LSCC	FGD1 →	-0.575	-0.212	.003	<.001	3	4
LUAD	AOC2 →	-0.373	-0.210	.001	.002	3	4
CCRCC	PRR15L →	+1.235	+0.259	<.001	<.001	3	4
BRCA	AGR3 →	+3.432	+0.502	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,738 associations by consensus.

TPRN vs TMEM237 — LSCC

Explore this scatter interactively →