TPRN

Across TCGA pan-cancer cohorts, TPRN RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TPRN’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where TPRN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TPRN is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

LIHC, KIRC, and BRCA are the cancer types where TPRN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPRN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.911	<.001	7	view →
KIRC	Male	II,III,IV	−0.687	<.001	7	view →
BRCA	All	III,IV	+1.789	<.001	6	view →
UCEC	All	All	+0.813	<.001	6	view →
LUAD	Female	All	−0.480	<.001	6	view →
STAD	All	All	+0.962	.001	5	view →
HNSC	Female	III,IV	−0.908	.001	4	view →
KICH	All	All	−0.484	.002	4	view →
COAD	All	All	−0.385	.006	4	view →
THCA	Male	All	+0.274	.002	4	view →
CHOL	All	All	+2.310	<.001	3	view →
PRAD	All	All	+0.693	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TPRN–LIHC

Open the LIHC breakdown →