TPRN

Across TCGA cell cohorts, TPRN mutation is significantly associated with the drug of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPRN-associated genes across cancer lineages are Crizotinib, Erlotinib, and PRT062607. Each is linked with TPRN in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRN-to-partner and partner-to-TPRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Crizotinib grouped by TPRN-low versus TPRN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRN→partner) and Y-score (partner→TPRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Crizotinib →	+0.419	+2.646	.042	.047	3	1
LARGE_INTESTINE	Erlotinib →	+0.521	+2.777	.043	.038	3	1
LARGE_INTESTINE	PRT062607 →	+0.670	+2.769	.007	.040	3	1
LARGE_INTESTINE	150412 →	+0.343	+2.777	.042	.038	3	1
LARGE_INTESTINE	630600 →	+0.736	+2.649	.017	.046	3	1
LARGE_INTESTINE	Masitinib →	+0.439	+2.652	.042	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Crizotinib by TPRN expression — LARGE_INTESTINE

Explore this box plot interactively →