TPRKBP1

Across TCGA pan-cancer cohorts, TPRKBP1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated TPRKBP1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TPRKBP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TPRKBP1 expression acts as an unfavorable survival marker, although some lineages such as OV and ESCA show a favorable association.

SKCM, OV, and KIRC are the cancer types where TPRKBP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	IV	0.016	0.541	.008	57	view →
OV	OS	Tertile	IV	0.541	0.291	.006	42	view →
KIRC	DFS	Tertile	IV	0.332	0.625	.030	30	view →
PAAD	OS	Tertile	All	0.261	0.482	.013	21	view →
ESCA	OS	Median	IV	0.698	0.222	.006	18	view →
MESO	DFS	Tertile	IV	0.130	0.405	.019	18	view →
CESC	OS	Tertile	II,III,IV	0.899	0.474	.033	12	view →
ACC	DFS	Tertile	IV	0.012	0.310	.002	12	view →
COAD	DFS	Tertile	IV	0.158	0.551	.007	9	view →
LIHC	OS	Tertile	All	0.620	0.794	.039	9	view →
GBM	DFS	Tertile	All	0.175	0.287	.007	8	view →
LGG	OS	Tertile	All	0.251	0.483	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

TPRKBP1–SKCM (DFS)

Open the SKCM breakdown →