TPRKB

Across TCGA pan-cancer cohorts, TPRKB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TPRKB data layer compared with 29 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TPRKB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TPRKB expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where TPRKB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.830	0.692	.004	18	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	4	view →
LUAD	DFS	Tertile	All	0.837	0.438	.038	2	view →
UCEC	DFS	Median	All	0.953	0.856	.026	2	view →
HNSC	DFS	Tertile	III,IV	0.918	0.746	.044	1	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.741	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TPRKB–PDAC (DFS)

Open the PDAC breakdown →