TPRKB

Across TCGA patient cohorts, TPRKB protein abundance is significantly associated with the RNA expression of many other genes, with 6,210 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TPRKB-associated genes across cancer lineages are OSGEP, COQ6, and GEMIN2. Each is linked with TPRKB in more than 5 cancer types. Because this analysis shows association rather than direction, both TPRKB-to-partner and partner-to-TPRKB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPRKB versus OSGEP in OV, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRKB→partner) and Y-score (partner→TPRKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	OSGEP →	+0.556	+0.431	<.001	<.001	3	6
BRCA	COQ6 →	+0.417	+0.270	.001	<.001	3	4
OV	GEMIN2 →	+0.419	+0.347	.008	.002	3	4
BRCA	TTC8 →	+0.542	+0.197	<.001	<.001	3	4
LUAD	ZC3H14 →	+0.396	+0.263	.001	<.001	3	4
BRCA	TRIP11 →	+0.435	+0.262	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,210 associations by consensus.

TPRKB vs OSGEP — OV

Explore this scatter interactively →