TPRG1-AS1

Across TCGA pan-cancer cohorts, TPRG1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TPRG1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TPRG1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types TPRG1-AS1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, HNSC, and BRCA are the cancer types where TPRG1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPRG1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.480	<.001	11	view →
HNSC	All	II,III,IV	+0.725	<.001	11	view →
BRCA	All	III,IV	−1.371	<.001	6	view →
KIRP	Male	All	−0.583	.001	6	view →
LUAD	All	II,III,IV	−0.512	.001	6	view →
CHOL	Male	All	−2.743	<.001	5	view →
KICH	All	All	−0.728	.011	5	view →
STAD	Male	IV	−0.205	.027	3	view →
LIHC	Female	All	−1.226	.001	2	view →
COAD	Female	III,IV	+0.190	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TPRG1-AS1–THCA

Open the THCA breakdown →