TPRA1

Across TCGA patient cohorts, TPRA1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPRA1-associated genes across cancer lineages are Ku80, EGFR_pY1068, and JNK2. Each is linked with TPRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRA1-to-partner and partner-to-TPRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TPRA1-low versus TPRA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRA1→partner) and Y-score (partner→TPRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.272	+2.179	.017	.034	3	2
UCEC	EGFR_pY1068 →	-0.353	-3.584	.003	.002	3	1
UCEC	JNK2 →	+0.285	+3.009	.002	.019	3	1
UCEC	Mre11 →	-0.109	-3.584	.008	.002	3	1
UCEC	p70-S6K_pT389 →	-0.181	-2.999	.049	.035	3	1
UCEC	Rad50 →	-0.232	-2.459	.048	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Ku80 by TPRA1 expression — UCEC

Explore this box plot interactively →