TPPP2

Across TCGA pan-cancer cohorts, TPPP2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TPPP2 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TPPP2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TPPP2 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUAD, LUSC, and SKCM are the cancer types where TPPP2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.090	0.709	<.001	12	view →
LUSC	DFS	Median	II,III,IV	0.139	0.663	.027	3	view →
SKCM	DFS	Median	III,IV	1.000	0.467	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TPPP2–LUAD (OS)

Open the LUAD breakdown →