TPPP

Across TCGA pan-cancer cohorts, TPPP Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TPPP data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher TPPP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TPPP expression acts as an unfavorable survival marker.

THYM, LUSC, and COAD are the cancer types where TPPP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	12	view →
COAD	OS	Median	All	0.001	0.871	<.001	12	view →
BLCA	OS	Median	III,IV	0.183	0.684	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TPPP–THYM (OS)

Open the THYM breakdown →