TPPP

Across TCGA pan-cancer cohorts, TPPP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TPPP data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TPPP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TPPP expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where TPPP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.569	0.316	.001	53	view →
LSCC	DFS	Quartile	All	0.874	0.588	.009	18	view →
CCRCC	DFS	Tertile	IV	0.861	0.108	.024	17	view →
LUAD	DFS	Tertile	II,III,IV	0.578	0.993	.001	16	view →
HNSC	DFS	Tertile	All	0.708	0.821	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TPPP–PDAC (DFS)

Open the PDAC breakdown →