TPO

Across TCGA patient cohorts, TPO protein abundance is significantly associated with the RNA expression of many other genes, with 2,071 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TPO-associated genes across cancer lineages are RASAL1, SH3GL3, and LINC01250. Each is linked with TPO in more than 1 cancer types. Because this analysis shows association rather than direction, both TPO-to-partner and partner-to-TPO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPO versus RASAL1 in UCEC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPO→partner) and Y-score (partner→TPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RASAL1 →	+1.240	+0.497	.009	.008	3	2
GBM	SH3GL3 →	+1.364	+0.340	<.001	<.001	3	2
UCEC	LINC01250 →	+1.254	+0.592	.004	.005	3	2
UCEC	PHYH →	-0.852	-0.640	.002	.002	3	1
UCEC	PI3 →	+2.368	+0.728	.002	.001	3	1
UCEC	EPB41L4A →	+1.230	+0.887	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,071 associations by consensus.

TPO vs RASAL1 — UCEC

Explore this scatter interactively →