TPMTP3

Across TCGA patient cohorts, TPMTP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,453 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TPMTP3-associated GO terms across cancer lineages are Regulation of mitochondrial gene expression, Telomere maintenance, and Positive regulation of post-translational protein modification. Each is linked with TPMTP3 in more than 5 cancer types. Because this analysis shows association rather than direction, both TPMTP3-to-partner and partner-to-TPMTP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrial gene expression grouped by TPMTP3-low versus TPMTP3-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPMTP3→partner) and Y-score (partner→TPMTP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of mitochondrial gene expression →	+0.070	+0.055	<.001	.005	3	5
ESCA	Telomere maintenance →	+0.070	+0.069	<.001	.007	3	5
UCEC	Positive regulation of post-translational protein modification →	+0.050	+0.029	<.001	<.001	3	5
STAD	Mitotic G2/M transition checkpoint →	+0.041	+0.044	<.001	.003	3	5
STAD	Intracellular iron ion homeostasis →	+0.038	+0.044	<.001	.001	3	5
ESCA	Mitochondrial genome maintenance →	+0.058	+0.037	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,453 associations by consensus.

Regulation of mitochondrial gene expression by TPMTP3 expression — ESCA

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