TPMTP2

Across TCGA pan-cancer cohorts, TPMTP2 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated TPMTP2 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher TPMTP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TPMTP2 expression acts as an unfavorable survival marker, although some lineages such as CESC and LAML show a favorable association.

THCA, CESC, and SKCM are the cancer types where TPMTP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	IV	0.163	0.837	<.001	70	view →
CESC	DFS	Tertile	II,III,IV	1.000	0.742	.005	48	view →
SKCM	DFS	Tertile	II,III,IV	0.574	0.708	.015	30	view →
MESO	OS	Tertile	IV	0.243	0.648	.010	27	view →
DLBC	OS	Quartile	All	0.445	0.896	.001	19	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
PAAD	OS	Tertile	II,III,IV	0.419	0.606	.010	18	view →
LAML	DFS	Median	All	0.473	0.275	.008	16	view →
ACC	OS	Tertile	II,III,IV	0.162	0.605	.005	15	view →
STAD	DFS	Quartile	II,III,IV	0.294	0.560	.024	10	view →
BLCA	OS	Tertile	III,IV	0.741	0.625	.032	9	view →
READ	OS	Tertile	IV	0.077	1.000	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

TPMTP2–THCA (DFS)

Open the THCA breakdown →