TPMTP2

Across TCGA pan-cancer cohorts, TPMTP2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TPMTP2’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where TPMTP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TPMTP2 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

UCEC, READ, and LUSC are the cancer types where TPMTP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPMTP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	IV	+0.275	.015	2	view →
READ	All	III,IV	+0.125	.001	2	view →
LUSC	All	All	−0.050	.017	2	view →
KIRC	Female	II,III,IV	+0.046	.028	2	view →
THCA	Male	All	−0.056	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TPMTP2–UCEC

Open the UCEC breakdown →