TPMT

Across TCGA patient cohorts, TPMT mutation is significantly associated with the RNA expression of many other genes, with 343 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPMT-associated genes across cancer lineages are RNU6-233P, MIR7150, and MIR8080. Each is linked with TPMT in more than 1 cancer types. Because this analysis shows association rather than direction, both TPMT-to-partner and partner-to-TPMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-233P grouped by TPMT-low versus TPMT-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPMT→partner) and Y-score (partner→TPMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-233P →	+0.262	+4.173	.002	.003	3	2
BRCA	MIR7150 →	+0.496	+5.575	<.001	.004	3	1
BRCA	MIR8080 →	+0.254	+7.471	<.001	.008	3	1
COAD	RNU6-552P →	+0.234	+5.136	<.001	.002	3	1
COAD	RNU6-451P →	+0.271	+4.666	<.001	.005	3	1
COAD	RNY4P9 →	+0.523	+4.730	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 343 associations by consensus.

RNU6-233P by TPMT expression — COAD

Explore this box plot interactively →