TPM1-AS

Across TCGA pan-cancer cohorts, TPM1-AS RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TPM1-AS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TPM1-AS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TPM1-AS is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, KICH, and BRCA are the cancer types where TPM1-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPM1-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.314	<.001	10	view →
KICH	All	All	−0.441	<.001	7	view →
BRCA	Female	All	−0.522	<.001	6	view →
LIHC	All	All	+0.135	<.001	5	view →
CHOL	Male	All	+0.948	<.001	4	view →
BLCA	Male	III,IV	−0.672	.026	3	view →
PRAD	All	All	+0.740	<.001	2	view →
UCEC	All	All	−0.368	.002	2	view →
THCA	Male	All	−0.158	.006	2	view →
STAD	All	All	−0.436	.030	1	view →
LUSC	Female	II,III,IV	−0.372	.037	1	view →
COAD	All	II,III,IV	−0.235	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TPM1-AS–KIRC

Open the KIRC breakdown →