Across TCGA patient cohorts, TPK1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,138 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TPK1-associated genes across cancer lineages are PIK3CG, C11orf21, and LY9. Each is linked with TPK1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TPK1-to-partner and partner-to-TPK1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPK1→partner) and Y-score (partner→TPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIK3CG →	+0.970	+0.750	<.001	<.001	3	7
HNSC	C11orf21 →	+0.694	+0.456	<.001	<.001	3	7
HNSC	LY9 →	+0.830	+0.489	<.001	<.001	3	7
LUAD	CHIT1 →	+1.226	+0.248	.001	.002	3	7
GBM	DOCK2 →	+1.097	+0.755	<.001	<.001	3	7
HNSC	FGD2 →	+1.002	+0.568	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,138 associations by consensus.

Exploration

TPK1 survival (RNA) · tumor vs normal (RNA) · all TPK1 data types