TPH1

Across TCGA patient cohorts, TPH1 protein abundance is significantly associated with the RNA expression of many other genes, with 655 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TPH1-associated genes across cancer lineages are PGAM5P1, MIR4460, and MIR5692C1. Each is linked with TPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPH1-to-partner and partner-to-TPH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPH1 versus PGAM5P1 in UCEC, with a Pearson correlation of 0.93.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPH1→partner) and Y-score (partner→TPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAM5P1 →	+0.203	+2.767	.003	.002	3	1
UCEC	MIR4460 →	+2.316	+2.767	.009	.002	3	1
UCEC	MIR5692C1 →	+3.850	+2.767	<.001	.002	3	1
UCEC	CCDC195 →	+1.833	+2.789	.006	.005	3	1
UCEC	TRMT10A →	+1.082	+0.590	.008	.003	2	1
UCEC	CPA6 →	+1.790	+0.619	.001	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 655 associations by consensus.

TPH1 vs PGAM5P1 — UCEC

Explore this scatter interactively →