TPGS2

Across TCGA patient cohorts, TPGS2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,449 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPGS2-associated genes across cancer lineages are INO80-AS1, SPEF1, and NXT2. Each is linked with TPGS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPGS2-to-partner and partner-to-TPGS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPGS2 versus INO80-AS1 in GBM, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPGS2→partner) and Y-score (partner→TPGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	INO80-AS1 →	-0.416	-0.345	.001	.001	3	2
BRCA	SPEF1 →	+1.743	+0.956	.002	.007	3	1
BRCA	NXT2 →	-0.936	-1.053	.006	.005	3	1
BRCA	RAB5C →	-0.773	-0.750	.008	<.001	3	1
BRCA	METTL8 →	+0.567	+0.915	.005	<.001	3	1
BRCA	RBCK1 →	+0.972	+1.043	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,449 associations by consensus.

TPGS2 vs INO80-AS1 — GBM

Explore this scatter interactively →