TPGS2

Across TCGA patient cohorts, TPGS2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPGS2-associated genes across cancer lineages are A-Raf_pS299, HER3_pY1289, and MEK1. Each is linked with TPGS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPGS2-to-partner and partner-to-TPGS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TPGS2-low versus TPGS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPGS2→partner) and Y-score (partner→TPGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.159	-3.000	.005	.036	3	1
UCEC	HER3_pY1289 →	+0.086	+2.189	.040	.034	3	1
UCEC	MEK1 →	+0.426	+3.169	.016	.019	3	1
UCEC	Notch1 →	+0.215	+2.459	.001	.020	3	1
UCEC	p62 Lck ligand →	+0.414	+2.179	.008	.034	3	1
UCEC	p90 RSK →	+0.247	+3.179	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

A-Raf_pS299 by TPGS2 expression — UCEC

Explore this box plot interactively →