TPGS2

Across TCGA cell cohorts, TPGS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,378 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TPGS2-associated GO terms across cancer lineages are Regulation of mitotic metaphase/anaphase transition, Regulation of sister chromatid segregation, and Regulation of mitotic sister chromatid separation. Each is linked with TPGS2 in more than 12 cancer types. Because this analysis shows association rather than direction, both TPGS2-to-partner and partner-to-TPGS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic metaphase/anaphase transition grouped by TPGS2-low versus TPGS2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPGS2→partner) and Y-score (partner→TPGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of mitotic metaphase/anaphase transition →	+0.139	+1.494	<.001	<.001	3	13
BREAST	Regulation of sister chromatid segregation →	+0.126	+1.520	<.001	<.001	3	13
STOMACH	Regulation of mitotic sister chromatid separation →	+0.128	+0.756	<.001	<.001	3	12
BREAST	Regulation of metaphase/anaphase transition of cell cycle →	+0.138	+1.501	<.001	<.001	3	12
BREAST	Cell division →	+0.096	+1.201	<.001	<.001	3	12
BLOOD_Myeloma	Regulation of cell cycle checkpoint →	+0.071	+0.978	.006	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,378 associations by consensus.

Regulation of mitotic metaphase/anaphase transition by TPGS2 expression — BREAST

Explore this box plot interactively →