TPGS2

Across TCGA cell cohorts, TPGS2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPGS2-associated genes across cancer lineages are CFHR2 and NCR3. Each is linked with TPGS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPGS2-to-partner and partner-to-TPGS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by TPGS2-low versus TPGS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPGS2→partner) and Y-score (partner→TPGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1
LARGE_INTESTINE	NCR3 →	+0.147	+3.554	.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CFHR2 by TPGS2 expression — LARGE_INTESTINE

Explore this box plot interactively →