TPCN2

Across TCGA patient cohorts, TPCN2 mutation is significantly associated with the RNA expression of many other genes, with 2,286 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPCN2-associated genes across cancer lineages are PHBP6, UHRF1, and SNORD116-12. Each is linked with TPCN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TPCN2-to-partner and partner-to-TPCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHBP6 grouped by TPCN2-low versus TPCN2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPCN2→partner) and Y-score (partner→TPCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PHBP6 →	+0.018	+4.099	<.001	.008	3	3
UCEC	UHRF1 →	+0.680	+1.818	.002	.002	3	2
HNSC	SNORD116-12 →	+0.650	+3.150	<.001	.006	3	2
HNSC	MIR206 →	+0.262	+4.696	<.001	<.001	3	2
LUSC	RN7SKP126 →	+0.071	+3.706	.008	.003	3	2
SKCM	RNU6-939P →	+0.309	+3.508	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,286 associations by consensus.

PHBP6 by TPCN2 expression — LUSC

Explore this box plot interactively →