TPCN2

Across TCGA cell cohorts, TPCN2 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPCN2-associated genes across cancer lineages are SLC22A2, IRGC, and KCNG4. Each is linked with TPCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPCN2-to-partner and partner-to-TPCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A2 grouped by TPCN2-low versus TPCN2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPCN2→partner) and Y-score (partner→TPCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC22A2 →	+0.213	+4.347	<.001	<.001	3	1
BLOOD_Lymphoma	IRGC →	+0.026	+3.765	.009	.008	3	1
BLOOD_Lymphoma	KCNG4 →	+0.019	+3.342	<.001	.008	3	1
BLOOD_Lymphoma	PFN3 →	+0.061	+4.342	<.001	<.001	3	1
LUNG_NSCLC_LUAD	TAS2R9 →	+0.061	+3.925	<.001	.005	3	1
LUNG_NSCLC_LUAD	DEFB118 →	+0.008	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

SLC22A2 by TPCN2 expression — BLOOD_Lymphoma

Explore this box plot interactively →