TPBG

Across TCGA patient cohorts, TPBG protein abundance is significantly associated with the RNA expression of many other genes, with 7,725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPBG-associated genes across cancer lineages are LOX, LOXL1, and FRMD6. Each is linked with TPBG in more than 4 cancer types. Because this analysis shows association rather than direction, both TPBG-to-partner and partner-to-TPBG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPBG versus LOX in OV, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPBG→partner) and Y-score (partner→TPBG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LOX →	+1.643	+0.567	<.001	<.001	3	4
OV	LOXL1 →	+0.913	+0.377	.005	.004	3	4
PDAC	FRMD6 →	+0.862	+0.665	<.001	<.001	3	4
OV	COL6A2 →	+1.494	+0.471	.002	<.001	3	4
HNSC	PHLDB2 →	+0.867	+0.352	.001	.007	2	5
OV	MMP14 →	+1.107	+0.470	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,725 associations by consensus.

TPBG vs LOX — OV

Explore this scatter interactively →