TPBG

Across TCGA pan-cancer cohorts, TPBG RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TPBG data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TPBG RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TPBG expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

ACC, SCLC, and BRCA are the cancer types where TPBG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.415	0.815	<.001	94	view →
SCLC	DFS	Tertile	All	0.478	0.113	<.001	50	view →
BRCA	OS	Tertile	III,IV	0.892	0.701	<.001	43	view →
MESO	DFS	Median	IV	0.181	0.528	.001	42	view →
HNSC	DFS	Median	IV	0.309	0.591	.004	31	view →
UVM	OS	Tertile	All	0.414	0.853	.004	30	view →
LUAD	OS	Tertile	All	0.756	0.861	.002	29	view →
SARC	DFS	Tertile	All	0.221	0.529	<.001	26	view →
SKCM	OS	Median	All	0.491	0.292	.005	22	view →
BLCA	DFS	Quartile	III,IV	0.292	0.604	.011	21	view →
STAD	DFS	Median	II,III,IV	0.449	0.605	.013	16	view →
UCEC	DFS	Median	IV	0.813	0.554	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TPBG–ACC (OS)

Open the ACC breakdown →