TPBG

Across TCGA patient cohorts, TPBG mutation is significantly associated with the RNA expression of many other genes, with 943 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPBG-associated genes across cancer lineages are TXNL4AP1, GLULP5, and MIR664A. Each is linked with TPBG in more than 2 cancer types. Because this analysis shows association rather than direction, both TPBG-to-partner and partner-to-TPBG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNL4AP1 grouped by TPBG-low versus TPBG-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPBG→partner) and Y-score (partner→TPBG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TXNL4AP1 →	+0.140	+5.251	<.001	<.001	3	3
BLCA	GLULP5 →	+0.040	+5.040	<.001	.002	3	2
BLCA	MIR664A →	+0.319	+3.735	.001	.005	3	2
LUAD	MTATP6P30 →	+0.064	+7.930	<.001	.008	3	2
STAD	MIR769 →	+0.480	+4.290	<.001	.008	3	2
BLCA	SNORD114-18 →	+0.515	+4.444	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 943 associations by consensus.

TXNL4AP1 by TPBG expression — BLCA

Explore this box plot interactively →