TPBG

Across TCGA patient cohorts, TPBG mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPBG-associated genes across cancer lineages are Notch1, Annexin-1, and STAT3_pY705. Each is linked with TPBG in more than 1 cancer types. Because this analysis shows association rather than direction, both TPBG-to-partner and partner-to-TPBG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TPBG-low versus TPBG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPBG→partner) and Y-score (partner→TPBG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.250	+3.013	<.001	.018	3	1
UCEC	Annexin-1 →	+0.612	+3.019	.020	.019	3	1
UCEC	STAT3_pY705 →	-0.324	-2.321	.013	.035	3	1
UCEC	4E-BP1 →	+0.390	+2.837	.004	.035	2	1
UCEC	MEK1 →	+0.556	+2.321	.002	.035	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Notch1 by TPBG expression — UCEC

Explore this box plot interactively →