TP73

Across TCGA patient cohorts, TP73 protein abundance is significantly associated with the RNA expression of many other genes, with 1,524 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TP73-associated genes across cancer lineages are THEMIS, PLAAT3, and H4C10P. Each is linked with TP73 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP73-to-partner and partner-to-TP73 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TP73 versus THEMIS in HNSC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP73→partner) and Y-score (partner→TP73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	THEMIS →	-0.900	-0.331	.003	.001	3	2
LSCC	PLAAT3 →	-0.930	-0.623	<.001	<.001	3	2
HNSC	H4C10P →	+0.953	+0.289	<.001	.008	3	2
HNSC	TP73-AS2 →	+0.945	+0.394	.002	<.001	3	2
HNSC	MLPH →	-1.176	-0.353	.001	.002	3	1
HNSC	ALG2 →	+0.646	+0.264	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,524 associations by consensus.

TP73 vs THEMIS — HNSC

Explore this scatter interactively →